Development of radioisotopes and radiopharmaceuticals for molecular radioimaging and targeted radiotherapy (nuclear medicine)
Responsible: Radu Leonte, Dana Niculae
The Radiopharmaceutical Research Center (RCC) within DFNA is a unitary research infrastructure, consisting of the TR19 cyclotron and hot cells for radiochemical processing and pharmaceutical preparation, intended mainly for research (fundamental, preclinical and clinical) and the development of radiopharmaceuticals, respectively the development of medical applications of nuclear physics. The main objectives of the RCC are:
➢ Improving the scientific and technical capability in the field of production and separation of radioisotopes for medical applications (diagnosis and therapy).
➢Contribution to improving the quality of life by translating research results into clinical applications and promoting a personalized medical approach. Creating a center of excellence for nuclear medicine imaging.
➢ Development of nuclear applications in related fields: biology, pharmacology, agriculture, materials physics, medicine.
➢ Production of short or medium life radioisotopes and their radiochemical processing.
➢ Development of state-of-the-art radiopharmaceuticals, intended for SPECT and PET functional imaging, early diagnosis by nuclear medicine and targeted systemic radiotherapy of cancer.
➢ Radiochemical syntheses, aseptic preparation, quality control, in vitro and in vivo preclinical testing on cell lines, respectively animal models, radiopharmaceutical preparation for clinical testing.
➢ Chemical and radiochemical tests by analytical and radioanalytical methods using complex radioanalytical and physico-chemical methods: chromatography with radio detection (HPLC, IC, GC, TLC), ligand tracer, dynamic light scattering, etc.
For more details please visit the dedicated CCR or the site erris.gov.ro
References:
[1] L. Matei et al., Modern Physics Letters AVol. 32, No. 17, 1740011, 2017
[2] R. A. Leonte et al., U.P.B. Sci. Bull., Series A, Vol. 79, Iss. 1, 2017
[3] I Ursu et al., Rom. Journ. Phys., Vol. 58, Nos. 9–10, P. 1327–1336, 2013